Chlortalidone is a benzothiadiazine (thiazide)-related diuretic with a long duration of action.
Thiazide and thiazide-like diuretics act primarily on the distal renal tubule (early convoluted part), inhibiting NaCl¯ reabsorption (by antagonising the Na+Cl¯ cotransporter) and promoting Ca++ reabsorption (by an unknown mechanism).
- Indications –
Treatment of arterial hypertension, essential or nephrogenic or isolated systolic. Treatment of stable, chronic heart failure of mild to moderate degree (New York Heart Association, NYHA: functional class II or III).
Oedema of specific origin
• Ascites due to cirrhosis of the liver in stable patients under close control.
• Oedema due to nephrotic syndrome.
The dosage of Hygroton/Chlortalidone should be individually titrated to give the lowest effective dose; this is particularly important in the elderly. Hygroton/Chlortalidone should be taken orally, preferably as a single daily dose at breakfast time.